The integrin alpha 6 beta 4 is a laminin receptor.
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چکیده
منابع مشابه
The integrin alpha 6 beta 4 is a laminin receptor
In this study, the putative laminin receptor function of the alpha 6 beta 4 integrin was assessed. For this purpose, we used a human cell line, referred to as clone A, that was derived from a highly invasive, colon adenocarcinoma. This cell line, which expresses the alpha 6 beta 4 integrin, adheres to the E8 and not to the P1 fragment of laminin. The adhesion of clone A cells to laminin is extr...
متن کاملIntegrin alpha 6 beta 4 mediates dynamic interactions with laminin.
We present here a novel form of dynamic adhesion in which both the integrin receptor and the ligand supporting dynamic adhesion have been identified. Laminar flow assays showed that laminin supported attachment of alpha 6 beta 4-positive cells in the presence of fluid shear stress (tau < or = 2 dyn/cm2), indicating that these cells adhered to laminin within a fraction of a second. Further incre...
متن کاملRegulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit
The alpha 6 beta 1 integrin is expressed on the macrophage surface in an inactive state and requires cellular activation with PMA or cytokines to function as a laminin receptor (Shaw, L. M., J. M. Messier, and A. M. Mercurio. 1990. J. Cell Biol. 110:2167-2174). In the present study, the role of the alpha 6 subunit cytoplasmic domain in alpha 6 beta 1 integrin activation was examined. The use of...
متن کاملThe major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin
Laminin is the first extracellular matrix protein expressed in the developing mouse embryo. It is known to influence morphogenesis and affect cell migration and polarization. Several laminin receptors are included in the integrin family of extracellular matrix receptors. Ligand binding by integrin heterodimers results in signal transduction events controlling cell motility. We report that the m...
متن کاملThe Integrin a6ß4 Is a Laminin Receptor
In this study, the putative laminin receptor function of the a6ß4 integrin was assessed . For this purpose, we used a human cell line, referred to as clone A, that was derived from a highly invasive, colon adenocarcinoma . This cell line, which expresses the a6ß4 integrin, adheres to the ES and not to the PI fragment of laminin . The adhesion of clone A cells to laminin is extremely rapid with ...
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ژورنال
عنوان ژورنال: The Journal of Cell Biology
سال: 1992
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.117.3.671